Prokaryotic Vs Eukaryotic Worksheet – Scaffolded
Introduction
Prokaryotic and eukaryotic cells are the building blocks of life, each with unique characteristics. These cellular distinctions are pivotal in understanding the fundamentals of biology. Therefore, a prokaryotic vs eukaryotic worksheet can help students comprehend this important yet sometimes challenging content.
In this blog post, we’ll explore the simplicity of prokaryotes to the complexity of eukaryotes, with a focus on preparing to engage your students with engaging content, including worksheets, to reinforce their comprehension.
Prokaryotic Cells
Prokaryotic cells are the simpler of the two cell types. They don’t have membrane-bound organelles like eukaryotic cells. Instead, they keep things simple and are quite small in size. One standout feature of prokaryotic cells is their tough cell wall, which provides structure and protection.
Examples of Prokaryotic Cells
Prokaryotic cells can be found all around us and impact human beings in many ways. Therefore, it’s essential to provide middle school science students with concrete examples.
Bacteria are one of the most common and well-known prokaryotic organisms. They come in various shapes and sizes, from the spherical cocci to the rod-shaped bacilli and spiral-shaped spirilla.
Different bacteria are present all over the environment and all over our bodies. They are responsible for the way dead organisms decompose and how our food digests.
Another fascinating example is archaea, which thrive in extreme environments like hot springs and deep-sea hydrothermal vents.

The diversity and importance of bacteria and archaea is a great starting point for activating prior knowledge and building schema around prokaryotic cells before introducing students to the more complex associated science content.
Eukaryotic Cells
Eukaryotic cells are a bit more complex than their prokaryotic counterparts. The key feature that defines them is the presence of membrane-bound organelles, which act like tiny organs within the cell, each with specific roles. These organelles make eukaryotic cells larger and more intricate compared to prokaryotic cells.
- Nucleus: One of the most critical organelles, the nucleus, acts as the cell’s control center. It houses the genetic material, DNA, and directs cellular activities. Think of it as the brain of the cell.
- Mitochondria: Often called the “powerhouses” of the cell, mitochondria generate energy through cellular respiration. They convert food into usable energy, essential for all cell functions.
- Endoplasmic Reticulum: This organelle comes in two types, rough and smooth. The rough endoplasmic reticulum is studded with ribosomes and involved in protein synthesis, while the smooth endoplasmic reticulum plays a role in lipid metabolism.
- Golgi Apparatus: Think of the Golgi apparatus as the cell’s post office. It modifies, sorts, and packages proteins and lipids, preparing them for transport within or outside the cell.
- Chloroplasts (for plant cells): Found exclusively in plant cells, chloroplasts are essential for photosynthesis, the process by which plants convert sunlight into energy.
Examples of Eukaryotic Cells
Eukaryotic cells abound in the natural world. Familiar examples include animal cells, plant cells, and even the cells in our bodies.
Plant cells, in particular, stand out due to the presence of chloroplasts, which enable photosynthesis. In contrast, animal cells lack chloroplasts but possess other vital organelles such as the nucleus and mitochondria.
These tangible examples help middle school science teachers illustrate the diversity of eukaryotic cells to their students, making the learning experience more engaging and relatable.
Teaching the Language of Prokaryotes and Eukaryotes
When introducing the concepts of prokaryotic and eukaryotic cells to middle school students, it’s essential to teach the associated language.
A common misconception is the difference between the nouns prokaryotes and eukaryotes and the adjectives prokaryotic and eukaryotic cells.

Let’s discuss the distinction in language. The term “prokaryote” refers to a group of unicellular organisms, such as bacteria and archaea, that are characterized by having prokaryotic cells. “Prokaryotic” is an adjective used to describe characteristics or features associated with prokaryotes or their cells. In other words, “prokaryote” refers to the organism, while “prokaryotic” describes the properties or attributes of that organism’s cells.
In teaching this difference to students, we need to give them ample practice in using the language. For example, in writing and speaking, students can practice the following sentences: Many eukaryotes are multicellular organisms. Prokaryotes lack membrane-bound cellular organelles.
Prokaryotic Vs Eukaryotic Worksheet
One way to help students better understand this concept is a “Prokaryotic vs Eukaryotic Worksheet.” Here at Lit Science, we view worksheets a bit differently than traditionally thought of. We use the term “worksheet” to describe graphic organizers that are customized to a specific instructional task or activity.
For example, a eukaryotes worksheet can contain a simple table with the term Eukaryote at the top. Then, the cells can contain the following categories: Complexity, #of cells, Organelles, DNA. Students write descriptions for each of the categories in the empty cells. Additional columns can be added for students to add a complete sentence that includes the name of the category, as well as a column for translation for students learning English.
Another example is a Venn Diagram. Through a Venn Diagram, students can compare and contrast prokaryotes and eukaryotes or prokaryotic cells and eukaryotic cells.
Venn diagrams are set up using two overlapping circles. In the example below, on one side, students write the characteristics that are unique to prokaryotic cells. On the other side, they write the characteristics that are unique to eukaryotic cells. In the middle, they write characteristics that apply to both.

Some ways to scaffold a Venn diagram for English learners is to include a model and the categories they should include in the diagram. This helps ELL students focus on what to write and relieves some of the cognitive burden of learning the content and language simultaneously.
Conclusion
In summary, teaching students about prokaryotic and eukaryotic cells is important in a middle school biology curriculum. These fundamental concepts serve as the cornerstone for understanding life sciences.
To effectively convey this knowledge, it’s essential to employ graphic organizers like Venn diagrams to support students in their understanding of the topic.
By fostering a strong foundation in these basic principles, we equip students with the critical thinking skills and scientific language they need to succeed.
Looking to save time while still providing your diverse students the support they to excel in their learning of prokaryotic vs. eukaryotic cells? Check out Lit Science’s prokaryotic vs. eukaryote reading comprehension worksheets.
